Objective: To probe into the intervention effects of rational application of antibiotics in pediatrics of primary hospitals based on new management mode of antibiotics in medical alliance. Methods: A total of 200 diagnosis and treatment logs of outpatient pediatric acute respiratory tract infection were randomly selected before and after rational application of antibiotics intervention from member units of primary hospitals of medical alliance in Affiliated Hospital of Yangzhou University. The application rate of antibiotics

drug combination rate

per capita cost of antibiotics

specimen delivery rate

selection of antibiotics and proportion of treatment that met standard guidelines were collected. The rational application of antibiotics before and after intervention was analyzed. The intervention effects of the new management mode of antibiotics based on medical alliance on the rational application of antibiotics in children of primary hospitals were evaluated. Results: After intervention

the application rate of antibiotics

drug combination rate of antibiotics and per capita cost of antibiotics in pediatric acute respiratory tract infection in primary hospitals decreased (P<0.05)

the specimen delivery rate

selection of antibiotics and proportion of treatment that met standard guidelines increased (P<0.05). Conclusion: New management mode of antibiotics based on medical alliance can guide and intervene the rational application of antibiotics in pediatrics of primary hospitals and effectively improve the rational application level of antibiotics in pediatrics of primary hospitals.